Stereochemistry of Hydrogen Transfer from Pyridine Nucleotides Catalyzed by Delta4-3-Oxosteroid 5beta-Reductase and 3alpha-Hydroxysteroid Dehydrogenase from Rat Liver
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چکیده
منابع مشابه
Activation of human liver 3alpha-hydroxysteroid dehydrogenase by clofibrate derivatives.
The NADP+-dependent dehydrogenase activity of a predominant isoenzyme of human liver 3alpha-hydroxysteroid dehydrogenase was activated by antihyperlipidemic drugs, such as bezafibrate and clinofibrate, and by clofibric acid and fenofibric acid (active metabolites of clofibrate and fenofibrate, respectively). The optimal pH of the activation by the drugs was about 7.5, and the concentrations giv...
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Several flavoproteins which oxidize reduced pyridine nucleotides have been observed to catalyze an exchange reaction between the protons of the medium and the reduced pyridine nucleotide (1, 2) as well as to mediate reduction of analogues of pyridine nucleotides by reduced pyridine nucleotides (3). Weber, Kaplan, San Pietro, and Stolzenbach (2) have made isotope studies of the analogue reductio...
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Rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating steroid hormones and may contribute to the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiols to reactive o-quinones with the concomitant generation of reactive oxygen species. The 3alpha-HSD/DD gene has been ...
متن کاملDirect Hydrogen Transfer from Reduced Pyridine Nucleotides to Microsomal Cytochrome b, Reductase*
On the basis of several types of experiments (2-7), a mechanism was proposed (7) for the oxidation of reduced pyridine nucleotides by cytochrome bh reductase (1.6.2.2, NADH-cytochrome bs oxidoreductase). According to this scheme, initially an oxidized flavoprotein-reduced pyridine nucleotide complex is formed involving several nucleotide-protein interactions. This is followed by the formation o...
متن کاملDirect hydrogen transfer from reduced pyridine nucleotides to microsomal cytochrome b5 reductase.
On the basis of several types of experiments (2-7), a mechanism was proposed (7) for the oxidation of reduced pyridine nucleotides by cytochrome bh reductase (1.6.2.2, NADH-cytochrome bs oxidoreductase). According to this scheme, initially an oxidized flavoprotein-reduced pyridine nucleotide complex is formed involving several nucleotide-protein interactions. This is followed by the formation o...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1970
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1970.tb00823.x